Inverse relationship between seizure expression and extrasynaptic NMDAR function following chronic NMDAR inhibition
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منابع مشابه
PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity.
Underexpression of the transcriptional coactivator PGC-1α is causally linked to certain neurodegenerative disorders, including Huntington's Disease (HD). HD pathoprogression is also associated with aberrant NMDAR activity, in particular an imbalance between synaptic versus extrasynaptic (NMDAR(EX)) activity. Here we show that PGC-1α controls NMDAR(EX) activity in neurons and that its suppressio...
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Prolonged calpain activation is widely recognized as a key component of neurodegeneration in a variety of pathological conditions. Numerous reports have also indicated that synaptic activation of NMDA receptors (NMDARs) provides neuroprotection against a variety of insults. Here, we report the paradoxical finding that such neuroprotection involves calpain activation. NMDAR activation in culture...
متن کاملBrief Communications PGC-1 Negatively Regulates Extrasynaptic NMDAR Activity and Excitotoxicity
Underexpression of the transcriptional coactivator PGC-1 is causally linked to certain neurodegenerative disorders, including Huntington’s Disease (HD). HD pathoprogression is also associated with aberrant NMDAR activity, in particular an imbalance between synaptic versus extrasynaptic (NMDAR ) activity. Here we show that PGC-1 controls NMDAR EX activity in neurons and that its suppression cont...
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Long-term potentiation of NMDA-receptor-mediated synaptic transmission (NMDAR-LTP) is a little-understood form of plasticity. In the present study, we investigated whether NMDAR-LTP in the dentate gyrus involves recruitment of extrasynaptic NMDARs, because NMDARs are expressed both synaptically and extrasynaptically with evidence for subtype differences at different locations. We show that befo...
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Correspondence: John E. Lisman 9 Department of Biology and Volen Center for Complex Systems, 10 Brandeis University, MS 008 11 415 South Street, 12 Waltham, Massachusetts 02454 13 Email: [email protected] 14 Tel: (781) 736-3145 15 Fax: (781) 736-3107 16 17 Numbers of pages: 23 18 Number of words in the Abstract: 242 19 Number of words in the Introduction: 722 20 Number of words in the Discuss...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2010
ISSN: 0013-9580,1528-1167
DOI: 10.1111/j.1528-1167.2010.02621.x